Application Notes

Liquid Handling

Generating High-Quality cDNA Libraries for Efficient Sequencing of T-cell Receptor mRNA from Single Cells

Application Note   |  Mantis Liquid Dispenser

rhTCRseq enables efficient TCR analysis at a single-cell level, supported by Mantis Liquid Dispenser for high-quality cDNA libraries.

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Accelerating Research with Organoid Disease Models Using Automated Imaging and Dispensing

Poster   |   Mantis Liquid Dispenser

Effective automated dispensing using the Mantis (Formulatrix) in combination with live-cell image analysis on the IncuCyte SX5 (Sartorius) opens up the possibility of running high-scale organoid applications such as small molecule screens, quantitative quality assurance processes, and high-volume expansion experiments.

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Filtration

Fast Lab-Scale Protein Refolding by Filter Dialysis on the µPulse TFF System

Application Note   |   µPulse – TFF System

The µPulse, a lab-scale TFF system, offers customizable pressures for protein refolding, yielding faster and higher specific activity results compared to equilibrium dialysis. This applies broadly to buffer exchange scenarios.

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Fast Formulation of a Purified Recombinant L-asparaginase Using µPulse – TFF System

Application Note   |   µPulse – TFF System

The µPulse filter chips can be cleaned in place and reused several times with negligible difference in filtration rates. We conclude that the use of the µPulse – TFF system is a fast, scalable, and cost-effective approach for formulation of the purified recombinant proteins, and other biomolecules.

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Single-step Purification and Formulation of Antibody-drug Conjugates Using the µPulse – TFF System

Poster   |   µPulse – TFF System

The µPulse – TFF system by Formulatrix addresses this limitation with a miniaturized design by combining TFF with microfluidic pumping technology on a filter chip. This footprint reduces the hold-up volume to 0.65 mL, which is up to 100% recoverable.

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Gentle Formulation of Plasma Derived Extracellular Vesicles with the μPulse – TFF System

Application Note   |   µPulse – TFF System

Learn how the μPulse – TFF system achieved 97-98% particle retention, ensuring a robust and efficient workflow for EV isolation and concentration.

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Protein Crystallization

AI-Powered Crystallization Experiment Scoring by Sherlock: Enhancing Efficiency, Accuracy, and Confidence in Experimental Outcomes

Application Note   |   Rock Maker – Protein Crystallization Software

Learn about Formulatrix’s Sherlock AI—an advanced tool that automates crystal identification in complex drops, outperforming previous models like MARCO.

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Cell Culture

iPSC Maintenance in a 6-well Plate Using the Cellmatic™

Application Note   |   Cellmatic – Automated Cell Culture

Discover how the Cellmatic automates iPSC maintenance in 6-well plates with imaging, media exchange, and passaging for consistent, high-quality cultures.

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Automated Gentle Media Exchange for Loosely Adherent HEK-293T Cells with the Reagent Exchanger (RX)

Application Note   |   Reagent Exchanger – Automated Plate Washer

Learn how the Formulatrix Reagent Exchanger (RX) gently automates media exchange for loosely adherent HEK-293T cells, minimizing detachment and ensuring reproducibility.

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