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What is Cellmatic, and what does it automate?
Cellmatic is a fully automated cell culture system that performs cell culture workflows from start to finish, including feeding, splitting, expansion, plating, and differentiation. The system continuously monitors cell growth and executes culture tasks based on predefined schedules or confluency triggers, reducing manual labor while improving consistency and reliability in cell culture workflows.

What hardware components are integrated within the Cellmatic?
Cellmatic integrates liquid handlers (FLO i8 PD and the high-throughput Reagent Exchanger), for automated feeding, passaging, and plating, an imager for monitoring cell growth, a CO₂-controlled incubator for culture plate storage, and a refrigerated dispenser for media and reagents. Labware storage cabinets support external plate and consumable loading, while autonomous Rover plate handlers move plates between subsystems. All components are coordinated through intelligent scheduling software for seamless automation.

How does the Cellmatic handle plate movement and storage?

Cellmatic offers flexible plate storage capacity that can be configured to meet your needs. Wireless Rover robots transport plates gently and spill-free between incubators, imagers, and handling stations, with adjustable slow or normal speed motion. A built-in scanner ensures accurate plate detection and placement throughout the system.

What cell culture workflows does the Cellmatic support?
The Cellmatic excels across stem cell differentiation, cell line development, high-throughput plating, permeability assays, immunology studies, and routine maintenance and expansion, making it a versatile solution for adherent cell workflows.

What liquid handling workflows are supported?
Cellmatic supports seeding, media exchange, harvesting, cell counting, reagent mixing, and plating. The FLO i8 PD liquid handler is used for dissociating cells, passaging, and cell counting, while the Reagent Exchanger performs gentle, but fast, media exchanges, compatible with organoids and stem cells. 

How scalable is the Cellmatic system for long-term workflows?
The Cellmatic's scheduler can support long-term formats like stem cell differentiation over weeks to months. Users program triggers like confluency or time-based splitting, and then leave the system to manage the process. Month-long differentiation protocols can be easily defined with the intuitive software user interface.

Does Cellmatic support high-throughput experiments?
Yes, Cellmatic can plate many cell lines in parallel, reduce manual labor by using plates instead of flasks, and support multi-user workflows efficiently. The Reagent Exchanger also enables high-throughput processing with its 96-nozzle dispenser, allowing rapid media exchange and plating across multiple wells simultaneously.

Can the Cellmatic be configured for regulatory compliance?
Currently, Cellmatic is designed for research and development use. Work is underway to develop features that will support GMP and regulatory-compliant workflows in the future.

What support and validation resources are available?
Cellmatic includes continuous CCTV surveillance and is monitored 24/7 by the FMLX support team. If any errors occur, the team is immediately notified and can log in remotely to resolve issues, with 95% of errors fixed within 30 minutes without disturbing the cells. Additional resources include webinars, specification documents, and expert guidance from product managers to support the implementation and optimization of workflows.

How does the scheduling software work?
The Cellmatic uses intuitive, dynamic scheduling that enables users to define operations like feeding intervals or to trigger passaging based on confluency without the need to code. Users can run multiple workflows in parallel, with Cellmatic interweaving tasks automatically for efficient operation.

Can researchers monitor and control workflows remotely?
Yes, Cellmatic's web-based interface allows researchers to monitor workflows in real time and receive notifications by email or text. Integrated CCTV cameras inside the system provide additional visual monitoring, helping track progress and ensure smooth operation even when accessing the system remotely.

How does the Cellmatic minimize reagent waste?
Cellmatic minimizes waste by filling reservoirs on demand inside the refrigerated storage, delivering only the media or reagent needed for each workflow. This eliminates long tubing from reagent bottles to liquid handlers, reducing flushing and conserving valuable media while maintaining precise, low-dead-volume dispensing.

How does Cellmatic monitor cell growth?
Cellmatic includes a built-in imager that captures daily images of cell cultures, allowing researchers to track growth, confluency, and overall culture health in real time.

What environmental controls does Cellmatic have?
Cellmatic maintains sterile and consistent culture conditions with HEPA filtration, VHP sterilization, and precise CO₂, temperature, and humidity control in the incubators.