自动化您的蛋白质结晶工作流程
管理整个蛋白质结晶实验过程,从设计到免去成像查看和分析,全部通过 ROCK MAKER® 一款软件完成。
可靠+可重复的蛋白滴设置
NT8 v4 是一款快速、纳升体积的液体处理器,具有用于蛋白质结晶的液滴分配功能,包括脂质立方相 (LCP) 实验。 8 头吸液头可吸取并分配 10 nL 至 1.5 μL 的液滴。
- 设置悬滴、坐滴、微批次、内消旋脂质立方相 (LCP) 滴、添加剂和接种实验
- 8 头吸液头可吸取并分配 10 nL 至 1.5 μL 的液滴
- 可重复使用的吸头让您可以选择在每次分配后处理吸头或重复使用它们,以降低成本和环境浪费
- 比例控制主动加湿最大限度地减少样品蒸发并提高实验重现性
轻松构建蛋白质结晶屏幕
FORMULATOR Screen Builder 是专为蛋白质晶体学设计的下一代液体处理器。 该系统采用专利微流体技术来分配多达 34 种不同的成分。 96 个喷嘴的分配芯片可以将任何体积、任何粘度的任何成分分配到任何孔中。
- 获得专利的微隔膜泵可将 200 nl 及以上的体积分配到任何微孔板中,甚至是深孔板和非 SBS VDX/Linbro 板
- 集成条形码扫描仪自动加载实验和成分数据,而瓶子传感器自动了解成分所在的位置
- 由于不需要消耗品,因此可以降低实验室的成本和对环境的影响
- 封闭的配料容器可防止蒸发、污染和有毒烟雾逸出

寻找 LCP 晶体生长的最佳条件...
无需等待您的水晶。
在设置蛋白质结晶实验之前,您可以使用光漂白后荧光恢复 (FRAP) 快速筛选 LCP 条件。 FRAP 是一种光学技术,用于评估蛋白质在 LCP 液滴中移动的容易程度。 如果蛋白质聚集,或者 LCP 结构塌陷,蛋白质将不会扩散,因此永远不会结晶。
- 加速结晶方法并排除次优条件,而无需等待晶体生长
- 自动化且用户友好的系统只需点击几下按钮即可启动对您的板的完整分析
- 所有结果和分析都集成到 FORMULATRIX 的蛋白质晶体学专用软件实验室管理软件(ROCK MAKER 和 ROCK IMAGER)中
FRAP 是与 Vadim Cherezov (TSRI) 和 Ray Stevens 领导的 JCIMPT 中心合作开发的,并得到 NIH 结构生物学共同基金的支持。
通过清晰的成像了解更多关于您的蛋白滴的信息
ROCK IMAGER 是最值得信赖的蛋白质晶体学成像仪,被全球十大制药公司和许多知名学术中心使用。
使用多种成像技术对您的液滴进行成像,使您能够更多地了解蛋白质液滴,包括可见光、紫外线、多荧光成像、FRAP 和 SONICC。
- 多种型号可满足您的预算和工作流程,可对单个板最多 970 个 SBS 板或 1500 个 LCP 板进行成像
- 通过 ROCK IMAGER API 与 ROCK MAKER 或您当前的结晶软件无缝集成
- 温度调节选项可实现 30°C 至 4°C 的精确温度控制
- 提供多种板选项,包括 SBS、Linbro、Nextal、Terasaki/HLA 和 LCP 板
寻找 LCP 晶体生长的最佳条件...
无需等待您的水晶。
手性晶体二阶非线性成像 (SONICC) 是蛋白质晶体可视化的终极成像技术,可以肉眼明确地发现埋藏在沉淀物中的晶体或亚微米晶体。 二次谐波发生 (SHG) 和紫外线双光子激发荧光 (UV-TPEF) 两种强大的技术结合在全自动成像仪中,可快速对高通量蛋白质结晶板进行成像并准确识别蛋白质晶体。
- 晶体在纯黑色背景下呈现白色,即使在黑暗的环境中也能帮助您识别晶体
- 只需看一眼盘子的缩略图即可快速找到难以看到的晶体
- 检测极薄晶体、<1 μm 的微晶体以及双折射 LCP 中模糊的晶体
- 明确区分沉淀物和晶体
- 确定哪些晶体是蛋白质,哪些不是
Automate Your Protein Crystallization Workflow
Manage the entire protein crystallization experimentation process, from design and dispense with imaging viewing and analysis, all from one software, Rock Maker®.
Rock Maker is a Laboratory Information Management System (LIMS) that is there every step of the way, with powerful yet easy-to-use tools that help you get the results you need quickly.
Rock Maker integrates with:
Rock Imager® - Crystallization Imagers
Trusted Worldwide by Labs of All Sizes
Our protein crystallization solutions are trusted by hundreds of laboratories worldwide, including at the top 10 leading pharmaceutical companies and at academic research institutes from around the globe.
Our clients come from a broad range of scientific studies and backgrounds. We have flexible automation and software solutions to fit your budget and workflow, regardless of lab size.
Reliable + Reproducible Protein Drop Setting
The NT8 - Drop Setter is a fast, nanoliter-volume liquid handler with drop dispensing capability for protein crystallization, including Lipidic Cubic Phase (LCP) experiments. The 8-tip head aspirates and dispenses drops from 10 nL to 1.5 μL.
- Set up hanging drop, sitting drop, microbatch, in meso Lipidic Cubic Phase (LCP) drops, additive, and seeding experiments
- 8-tip head aspirates and dispenses drops from 10 nL to 1.5 μL
- Reusable tips give you the option to dispose of tips after each dispense or reuse them to reduce costs and environmental waste
- Proportionally-Controlled Active Humidification minimizes sample evaporation and increases experiment reproducibility
Build Protein Crystallization Screens with Ease
The Formulator Screen Builder is a next-generation liquid handler designed specifically for protein crystallography. The system uses patented microfluidic technology to dispense up to 34 different ingredients. A 96-nozzle dispensing chip can dispense any volume of any ingredient of any viscosity into any well.
- The patented microdiaphragm pumps dispense volumes from 200 nl and up into any microplate, even deep well blocks and non-SBS VDX/Linbro plates
- Integrated barcode scanner automatically loads experiment and ingredient data while bottle sensors automatically know where ingredients are located
- Reduce your lab's costs and environmental impact, as no consumables are needed
- Closed ingredient containers prevent evaporation, contamination, and noxious fumes from escaping
Find the Optimal Conditions for LCP Crystal Growth...
Without Waiting on Your Crystals.
Prior to setting up protein crystallization experiments, you can quickly screen LCP conditions using Fluorescence Recovery After Photobleaching (FRAP). FRAP is an optical technique that assesses how easily protein is moving about in an LCP drop. If protein is aggregated, or the LCP structure is collapsed, the protein will not diffuse and, therefore, never crystallize.
- Accelerate crystallization methods and rule out suboptimal conditions without having to wait on the crystals growing
- Automated and user-friendly system requires a few clicks of a button to initiate a complete analysis of your plate
- All of the results and analyses are integrated into Formulatrix's protein crystallography-specific software lab management software (Rock Maker and Rock Imager)
FRAP was developed in collaboration with Vadim Cherezov (TSRI) and the JCIMPT center led by Ray Stevens and supported by the NIH Common Fund in Structural Biology.
Learn More About Your Protein Drops with Crystal Clear Imaging
Rock Imager is the most trusted imager for protein crystallography and is used by the top 10 pharmaceutical companies and many renowned academic centers worldwide.
Image your drops with multiple imaging technologies allowing you to discover more about your protein drops, including Visible Light, UV, Multi-Fluorescence Imaging, FRAP, and SONICC.
- Various models to fit your budget and workflow to image a single plate up to 970 SBS plates or 1500 LCP plates
- Seamless integration with Rock Maker or your current crystallization software via ROCK IMAGER API
- Temperature regulation options available for precise temperature control from 30°C down to 4°C
- Multiple plate options available, including SBS, Linbro, Nextal, Terasaki/HLA, and LCP plates
Remove the Guesswork.
SONICC Finds Crystals that Other Technologies Cannot.
The ultimate imaging technology in visualizing protein crystals, Second Order Nonlinear Imaging of Chiral Crystals (SONICC) definitively finds crystals buried in precipitate or submicron crystals naked to the eye. Two powerful technologies, Second Harmonic Generation (SHG) and Ultraviolet Two-Photon Excited Fluorescence (UV-TPEF) are combined together in a completely automated imager to quickly image your high throughput protein crystallization plates and positively identify protein crystals.
- Crystals appear white against a stark black background, helping you to identify crystals even in murky environments
- Quickly find difficult to see crystals simply by glancing at thumbnails of your plate
- Detect extremely thin crystals, microcrystals <1 μm, and crystals obscured in birefringent LCP
- Definitively distinguish between precipitate and crystals
- Determine which crystals are protein and which are not